Beyond the brain: widespread pathology in Huntington's disease

Exon 1 of the HD Gene with an Expanded CAG Repeat Is Sufficient to Cause a Progressive Neurological Phenotype in Transgenic Mice

Laura Mangiarini, Kirupa Sathasivam, Mary J. Seller et al. · Cell · 1996 · 3.1K citations · Full text

Life Sciences, Genetics, Molecular Genetics +17

Early mitochondrial calcium defects in Huntington's disease are a direct effect of polyglutamines

Alexander Panov, Claire‐Anne Gutekunst, Blair R. Leavitt et al. · Nature Neuroscience · 2002 · 1K citations

Life Sciences, Genetics, Neurology +13

Transcriptional Repression of PGC-1α by Mutant Huntingtin Leads to Mitochondrial Dysfunction and Neurodegeneration

Libin Cui, Hyunkyung Jeong, Fran Borovečki et al. · Cell · 2006 · 990 citations · Full text

Life Sciences, Genetics, Molecular Biology +16

Increased apoptosis and early embryonic lethality in mice nullizygous for the Huntington's disease gene homologue

Scott Zeitlin, Jeh-Ping Liu, Deborah L. Chapman et al. · Nature Genetics · 1995 · 794 citations

Life Sciences, Genetics, Molecular Genetics +14

Trehalose alleviates polyglutamine-mediated pathology in a mouse model of Huntington disease

Motomasa Tanaka, Yoko Machida, Sanyong Niu et al. · Nature Medicine · 2004 · 778 citations

Life Sciences, Neurology, Neuroscience +16