INDIRECT RECOGNITION OF DONOR HLA CLASS I PEPTIDES IN LUNG TRANSPLANT RECIPIENTS WITH BRONCHIOLITIS OBLITERANS SYNDROME1

Abstract

These data suggest that T cells from LTx recipients are sensitized to mismatched HLA class I antigens. The sensitization was significantly higher in LTx recipients with BOS compared with LTx recipients without BOS. Strategies to block T-cell responses generated by indirect allorecognition after lung transplantation may provide a means for the prevention or treatment of BOS in LTx recipients.