Peroxisome Proliferator‐Activated Receptors<i>α</i>and<i>γ</i>are Linked with Alcohol Consumption in Mice and Withdrawal and Dependence in Humans

Abstract

We provide convergent evidence using both mouse and human data for specific PPARs in alcohol action. Reduced EtOH intake in mice and the genetic association between AD or withdrawal in humans highlight the potential for repurposing FDA-approved PPARα or PPARγ agonists for the treatment of AD.