Concepedia

Synthesis of a novel C2-aryl substituted 1,2-unsaturated pyrrolobenzodiazepine

Gyoung‐Dong Kang, Philip W. Howard, David E. Thurston

Chemical Communications · 2003 · 17 citations · 5 references

DOI

Concepts

Abstract

A novel C2-aryl 1,2-unsaturated PBD (14) has been prepared via an enol triflate intermediate (8). The regiochemistry of triflation is dependent upon the point at which the reaction is performed during the synthetic route.

References

5

A Versatile and Highly Selective Hypervalent Iodine (III)/2,2,6,6-Tetramethyl-1-piperidinyloxyl-Mediated Oxidation of Alcohols to Carbonyl Compounds

A. DE MICO, Roberto Margarita, Luca Parlanti et al. · The Journal of Organic Chemistry · 1997 · 763 citations

, , +8

Design, Synthesis, and Evaluation of a Novel Pyrrolobenzodiazepine DNA-Interactive Agent with Highly Efficient Cross-Linking Ability and Potent Cytotoxicity

Stephen J. Gregson, Philip W. Howard, John A. Hartley et al. · Journal of Medicinal Chemistry · 2001 · 200 citations

, , +17

Total CD34 yield and CFU-GM as mobolisation and subsequent engraftment after high dose chemotherapy.

Daniel Epurescu, S Scholey, RJ Hinchliffe et al. · Research Explorer (The University of Manchester) · 1999 · 67 citations

, , +9

Effect of C2-exo unsaturation on the cytotoxicity and DNA-binding reactivity of pyrrolo[2,1-c][1,4]benzodiazepines

Stephen J. Gregson, Philip W. Howard, Kathryn E. Corcoran et al. · Bioorganic & Medicinal Chemistry Letters · 2000 · 37 citations

, , +9

Design, synthesis and in vitro cytotoxicity studies of novel pyrrolo[2,1-c][1,4]benzodiazepine (PBD)--polymade conjugates and 2,2'-PBD dimers.

Reddy Bs, Yalamati Damayanthi · PubMed · 2000 · 28 citations

, , +10