Efficient Cytosolic Delivery of siRNA Using HDL‐Mimicking Nanoparticles

Abstract

High-density lipoprotein (HDL)-mimicking peptide–phospholipid scaffold (HPPS) nanoparticles are used as a flexible and biocompatible nanocarrier for the delivery of small interfering RNA (siRNA). The direct cytosolic delivery ability of cholesterol-modified siRNA displayed by the nanoparticle results in the selective delivery of RNA interference (RNAi) to targeted cells. This provides a strategy to bypass endolysosomal trafficking, and makes HPPS a useful tool for therapeutic siRNA delivery. Detailed facts of importance to specialist readers are published as ”Supporting Information”. Such documents are peer-reviewed, but not copy-edited or typeset. They are made available as submitted by the authors. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.