Concepedia

Dextran sulfate acts as an endothelial cell protectant and inhibits human complement and natural killer cell-mediated cytotoxicity against porcine cells

Thomas Laumonier, Alexander J. Walpen, Christine Maurus, Paul Mohaçsi, Katja Matozan, Elena Korchagina, Nicolai V. Bovin, Bernard Vanhove, Jörg D. Seebach, Robert Rieben

Transplantation · 2003 · 65 citations · 25 references

DOI

Abstract

DXS binds to porcine cells and protects them from complement- and NK cell-mediated injury in vitro. It might therefore be used as a novel therapeutic strategy to prevent xenograft rejection and has potential for clinical application as an "EC protectant."

References

25

Production of α-1,3-Galactosyltransferase Knockout Pigs by Nuclear Transfer Cloning

Liangxue Lai, Donna Kolber‐Simonds, Kwang‐Wook Park et al. · Science · 2002 · 1.3K citations

Characterization of a human cell line (NK-92) with phenotypical and functional characteristics of activated natural killer cells.

Jiang-Hong Gong, Guitta Maki, Hans-G. Klingemann · PubMed · 1994 · 729 citations

Expression of heme oxygenase-1 can determine cardiac xenograft survival

Miguel P. Soares, Y. Lin, Josef Anrather et al. · Nature Medicine · 1998 · 614 citations

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Human complement regulatory proteins protect swine-to-primate cardiac xenografts from humoral injury

Kenneth R. McCurry, David L. Kooyman, Cristobal G. Alvarado et al. · Nature Medicine · 1995 · 538 citations

, , +10

Accommodation of vascularized xenografts: Expression of “protective genes” by donor endothelial cells in a host Th2 cytokine environment

Fritz H. Bach, Christiane Ferran, Paul Hechenleitner et al. · Nature Medicine · 1997 · 419 citations · Full text

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