Concepedia

Polymerase Chain Reaction and Transcription Using Locked Nucleic Acid Nucleotide Triphosphates

Rakesh N. Veedu, Birte Vester, Jesper Wengel

Journal of the American Chemical Society · 2008 · 85 citations · 23 references

DOI

Concepts

Abstract

Polymerase chain reaction amplification of a locked nucleic acid (LNA)-modified DNA strand and transcription reactions using LNA-A nucleoside 5'-triphosphate were successfully accomplished with DNA and RNA polymerases.

References

23

Systematic Evolution of Ligands by Exponential Enrichment: RNA Ligands to Bacteriophage T4 DNA Polymerase

Craig Tuerk, Larry Gold · Science · 1990 · 10.4K citations

, , +15

In vitro selection of RNA molecules that bind specific ligands

Andrew D. Ellington, Jack W. Szostak · Nature · 1990 · 9.7K citations

, , +13

Aptamers: An Emerging Class of Molecules That Rival Antibodies in Diagnostics

Sumedha D. Jayasena · Clinical Chemistry · 1999 · 2.1K citations · Full text

, , +16

LNA (Locked Nucleic Acids): Synthesis of the adenine, cytosine, guanine, 5-methylcytosine, thymine and uracil bicyclonucleoside monomers, oligomerisation, and unprecedented nucleic acid recognition

Alexei A. Koshkin, Sanjay K. Singh, Poul Nielsen et al. · Tetrahedron · 1998 · 1K citations

, , +16

LNA (locked nucleic acids): synthesis and high-affinity nucleic acid recognition

Sanjay K. Singh, Alexei A. Koshkin, Jesper Wengel et al. · Chemical Communications · 1998 · 770 citations

, , +16