Concepedia

Resveratrol attenuates doxorubicin-induced cardiomyocyte apoptosis in mice through SIRT1-mediated deacetylation of p53

Chi Zhang, Yansheng Feng, Shuxin Qu, Xing Wei, Honglin Zhu, Qi Luo, Min Liu, Guangwen Chen, Xianzhong Xiao

Cardiovascular Research · 2011 · 210 citations · 20 references

DOIFull text

Open access

Abstract

The protective effect of RES against DOX-induced cardiomyocyte apoptosis is associated with the up-regulation of SIRT1-mediated p53 deacetylation.

References

20

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hSIR2SIRT1 Functions as an NAD-Dependent p53 Deacetylase

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Negative Control of p53 by Sir2α Promotes Cell Survival under Stress

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Resveratrol prevents doxorubicin cardiotoxicity through mitochondrial stabilization and the Sirt1 pathway

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Fas-Mediated Apoptosis in Adriamycin-Induced Cardiomyopathy in Rats

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