Concepedia

Modulation of Doxorubicin-Induced Cardiac Dysfunction in Toll-Like Receptor-2–Knockout Mice

Naoki Nozaki, Tetsuro Shishido, Yasuchika Takeishi, Isao Kubota

Circulation · 2004 · 221 citations · 26 references

DOI

Abstract

These findings suggest that TLR-2 may play a role in the regulation of inflammatory and apoptotic mediators in the heart after Dox administration.

References

26

Differential Roles of TLR2 and TLR4 in Recognition of Gram-Negative and Gram-Positive Bacterial Cell Wall Components

Osamu Takeuchi, Katsuaki Hoshino, Taro Kawai et al. · Immunity · 1999 · 3.3K citations · Full text

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A family of human receptors structurally related to <i>Drosophila</i>  Toll

Fernando Rock, Gary Hardiman, Jackie C. Timans et al. · Proceedings of the National Academy of Sciences · 1998 · 1.7K citations · Full text

Cutting Edge: Heat Shock Protein 60 Is a Putative Endogenous Ligand of the Toll-Like Receptor-4 Complex

Koji Ohashi, Volker Burkart, Stefanie B. Flohé et al. · The Journal of Immunology · 2000 · 1.6K citations · Full text

Toll4 (TLR4) expression in cardiac myocytes in normal and failing myocardium

Stefan Frantz, Lester Kobzik, Young‐Dae Kim et al. · Journal of Clinical Investigation · 1999 · 646 citations · Full text

MyD88, an Adapter Protein Involved in Interleukin-1 Signaling

Kimberly Burns, Fabio Martinon, Christoph Esslinger et al. · Journal of Biological Chemistry · 1998 · 627 citations · Full text