P-Glycoprotein Efflux and Other Factors Limit Brain Amyloid β Reduction by β-Site Amyloid Precursor Protein-Cleaving Enzyme 1 Inhibitors in Mice

Control of Peripheral Nerve Myelination by the ß-Secretase BACE1

Michael Willem, Alistair N. Garratt, Božidar Novak et al. · Science · 2006 · 686 citations

Medicine, Neurobiology, Neuroscience +17

Passive Permeability and P-Glycoprotein-Mediated Efflux Differentiate Central Nervous System (CNS) and Non-CNS Marketed Drugs

Kelly M. Mahar Doan, Joan E. Humphreys, Lindsey O. Webster et al. · Journal of Pharmacology and Experimental Therapeutics · 2002 · 626 citations

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Bace1 modulates myelination in the central and peripheral nervous system

Xiangyou Hu, Caitlin W. Hicks, Wanxia He et al. · Nature Neuroscience · 2006 · 606 citations

Medicine, Neurobiology, Neuroscience +12

Beta-amyloid precursor protein of Alzheimer disease occurs as 110- to 135-kilodalton membrane-associated proteins in neural and nonneural tissues.

D. J. Selkoe, Marcia B. Podlisny, Catharine Joachim et al. · Proceedings of the National Academy of Sciences · 1988 · 578 citations · Full text

Life Sciences, Molecular Biology, Neuroscience +15

Brain to Plasma Amyloid-β Efflux: a Measure of Brain Amyloid Burden in a Mouse Model of Alzheimer's Disease

Ronald B. DeMattos, Kelly R. Bales, David J. Cummins et al. · Science · 2002 · 565 citations

Life Sciences, Neurology, Neuroscience +15