Concepedia

Expansion of CD4<sup>+</sup>CD25<sup>+</sup>FoxP3<sup>+</sup> regulatory T cells in hepatitis C virus‐related chronic hepatitis, cirrhosis and hepatocellular carcinoma

Kai Yoshizawa, Hiroshi Abe, Yasuhito Kubo, Takuya Kitahara, Ryoichi Aizawa, Mika Matsuoka, Yoshio Aizawa

Hepatology Research · 2010 · 35 citations · 39 references

DOI

Abstract

We observed an increase in Treg cells in HCV-related chronic liver disease, particularly in HCC, and these cells were shown to be memory-type Treg cells.

References

39

Control of Regulatory T Cell Development by the Transcription Factor <i>Foxp3</i>

Shohei Hori, Takashi Nomura, Shimon Sakaguchi · Science · 2003 · 8K citations

, , +24

Foxp3 programs the development and function of CD4+CD25+ regulatory T cells

Jason D. Fontenot, Marc A. Gavin, Alexander Y. Rudensky · Nature Immunology · 2003 · 7.6K citations

, , +9

Management of Hepatocellular Carcinoma *

Jordi Bruix, Morris Sherman · Hepatology · 2005 · 5.9K citations · Full text

Signaling by intrathymic cytokines, not T cell antigen receptors, specifies CD8 lineage choice and promotes the differentiation of cytotoxic-lineage T cells

Jung‐Hyun Park, Stanley Adoro, Terry I. Guinter et al. · Nature Immunology · 2010 · 5.8K citations · Full text

, , +10

Immunologic self-tolerance maintained by activated T cells expressing IL-2 receptor α-chains (CD25). Breakdown of a single mechanism of self-tolerance causes various autoimmune diseases

Shimon Sakaguchi, N Sakaguchi, M Asano et al. · The Journal of Immunology · 1995 · 5.4K citations