Dietary cholesterol, rather than liver steatosis, leads to hepatic inflammation in hyperlipidemic mouse models of nonalcoholic steatohepatitis† - Concepedia

Concepedia

Publication | Open Access

Dietary cholesterol, rather than liver steatosis, leads to hepatic inflammation in hyperlipidemic mouse models of nonalcoholic steatohepatitis†

DOI Full Paper Access

458

Citations

24

References

2008

Year

Kristiaan Wouters, Patrick J. van Gorp, Veerle Bieghs, Marion J. Gijbels, Hans Duimel, Dieter Lütjohann, Anja Kerksiek, Roger van Kruchten, Nobuyo Maeda, Bart Staels,

Abstract

These findings indicate that dietary cholesterol, possibly in the form of modified plasma lipoproteins, is an important risk factor for the progression to hepatic inflammation in diet-induced NASH.

References

	Year	Citations
Molecular mediators of hepatic steatosis and liver injury Jeffrey D. Browning, Jay D. Horton Journal of Clinical Investigation Metabolic DisorderImmunologyPathologyFatty Liver DiseaseOxidative Stress	2004	1.8K
Hypercholesterolemia in low density lipoprotein receptor knockout mice and its reversal by adenovirus-mediated gene delivery. S Ishibashi, Mark S. Brown, Joseph L. Goldstein, Journal of Clinical Investigation Metabolic SyndromeLipid DisorderCholesterol ContentBiochemistryMedicine	1993	1.6K
Inhibiting triglyceride synthesis improves hepatic steatosis but exacerbates liver damage and fibrosis in obese mice with nonalcoholic steatohepatitis Kanji Yamaguchi, Liu Yang, Shannon J. McCall, Hepatology	2007	992
Mitochondrial free cholesterol loading sensitizes to TNF- and Fas-mediated steatohepatitis Francisca G. Caballero, Anna Colell, Albert Morales, Cell Metabolism Lipid PeroxidationImmunologyPathologyFatty Liver DiseaseOxidative Stress	2006	594
Lipid-induced oxidative stress causes steatohepatitis in mice fed an atherogenic diet Naoto Matsuzawa, Toshinari Takamura, Seiichiro Kurita, Hepatology	2007	503
Pathogenesis of type III hyperlipoproteinemia (dysbetalipoproteinemia): questions, quandaries, and paradoxes Robert W. Mahley, Yadong Huang, Stanley C. Rall Journal of Lipid Research	1999	439
Hepatocyte Apoptosis, Expression of Death Receptors, and Activation of NF-κB in the Liver of Nonalcoholic and Alcoholic Steatohepatitis Patients Paulo S. Ribeiro, Helena Cortez‐Pinto, Susana Solá, The American Journal of Gastroenterology	2004	379
Genetic control of inflammatory gene induction and NF-kappa B-like transcription factor activation in response to an atherogenic diet in mice. Feng Liao, Ali Andalibi, Frederick C. deBeer, Journal of Clinical Investigation Lipid PeroxidationImmunologyOxidative StressInflammationMetabolic Syndrome	1993	293
NF-κB Activation, Rather Than TNF, Mediates Hepatic Inflammation in a Murine Dietary Model of Steatohepatitis Aileen Dela Peňa, Isabelle Leclercq, Jacqueline Field, Gastroenterology InflammationMetabolic Associated SteatohepatitisHepatologyLiver PhysiologyImmune Regulation	2005	280
Early diet-induced non-alcoholic steatohepatitis in APOE2 knock-in mice and its prevention by fibrates Ronit Shiri‐Sverdlov, Kristiaan Wouters, Patrick J. van Gorp, Journal of Hepatology InflammationMetabolic SyndromeHepatologyMedicineLiver Physiology	2005	239

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