A Liver-Derived Secretory Protein, Selenoprotein P, Causes Insulin Resistance

Hirofumi Misu, Toshinari Takamura, Hiroaki Takayama, +24

Cell Metabolism

Metabolic SyndromeHepatologyBiochemistryLiver PhysiologyDiabetes +9

Increased oxidative stress precedes the onset of high-fat diet–induced insulin resistance and obesity

Naoto Nagata, Toshinari Takamura, Hitoshi Ando, +8

Metabolism

ObesityMetabolic SyndromeNutritionMetabolic DisorderPhysiology +7

Lipid-induced oxidative stress causes steatohepatitis in mice fed an atherogenic diet

Naoto Matsuzawa, Toshinari Takamura, Seiichiro Kurita, +9

Hepatology

Palmitate Induces Insulin Resistance in H4IIEC3 Hepatocytes through Reactive Oxygen Species Produced by Mitochondria

Seiji Nakamura, Toshinari Takamura, Naoto Nagata, +9

Journal of Biological Chemistry

Insulin Resistance Accelerates a Dietary Rat Model of Nonalcoholic Steatohepatitis

Tsuguhito Ota, Toshinari Takamura, Seiichiro Kurita, +9

Gastroenterology

ObesityMetabolic SyndromeInsulin ResistanceMedicineLiver Physiology +8

Metformin Prevents and Reverses Inflammation in a Non-Diabetic Mouse Model of Nonalcoholic Steatohepatitis

Yuki Kita, Toshinari Takamura, Hirofumi Misu, +16

PLoS ONE

Proteasome Dysfunction Mediates Obesity-Induced Endoplasmic Reticulum Stress and Insulin Resistance in the Liver

Toshiki Otoda, Toshinari Takamura, Hirofumi Misu, +21

Diabetes

Inverse Correlation between Serum Levels of Selenoprotein P and Adiponectin in Patients with Type 2 Diabetes

Hirofumi Misu, Kazuhide Ishikura, Seiichiro Kurita, +6

PLoS ONE

Histological Course of Nonalcoholic Fatty Liver Disease in Japanese Patients

Erika Hamaguchi, Toshinari Takamura, Masaru Sakurai, +9

Diabetes Care

Obesity Upregulates Genes Involved in Oxidative Phosphorylation in Livers of Diabetic Patients

Toshinari Takamura, Hirofumi Misu, Naoto Nagata, +8

Obesity

Metabolic DisorderDiabetic PatientsFatty Liver DiseaseRedox BiologyInsulin Signaling +15