A Strong Candidate for the Breast and Ovarian Cancer Susceptibility Gene <i>BRCA1</i>

Yoshio Miki, Jeffrey Swensen, Donna Shattuck-Eidens, +42

Science

Breast OncologyEngineeringGeneticsBrca1 GeneTumor Biology +14

Association of BRCA1 with Rad51 in Mitotic and Meiotic Cells

Ralph Scully, Junjie Chen, Annemieke W. Plug, +5

Cell

<i>BRCA1</i> Mutations in Primary Breast and Ovarian Carcinomas

P. Andrew Futreal, Qingyun Liu, Donna Shattuck-Eidens, +24

Science

Requirement of ATM-Dependent Phosphorylation of Brca1 in the DNA Damage Response to Double-Strand Breaks

David Cortez, Yi Wang, Jun Qin, +1

Science

Dna DamageCheckpoint Kinase AtmMolecular BiologyCell DeathMolecular Genetics +15

Dynamic Changes of BRCA1 Subnuclear Location and Phosphorylation State Are Initiated by DNA Damage

Ralph Scully, Junjie Chen, Robert Ochs, +4

Cell

ChromatinGenome InstabilityDynamic ChangesDna DamageChromatin Remodeling +5

p53-Dependent apoptosis suppresses tumor growth and progression in vivo

Holly Symonds, Leonard Krall, Lee Ann Remington, +4

Cell

Tumor BiologyMedicineApoptosisP53-dependent Apoptosis SuppressesCell Death +5

Centrosome Amplification and a Defective G2–M Cell Cycle Checkpoint Induce Genetic Instability in BRCA1 Exon 11 Isoform–Deficient Cells

Xiaoling Xu, Zoë Weaver Ohler, Steven P. Linke, +6

Molecular Cell

Genome InstabilityChromosome DynamicsCell DivisionMedicineBrca1 Exon 11 +8

Conditional mutation of Brca1 in mammary epithelial cells results in blunted ductal morphogenesis and tumour formation

Xiaoling Xu, Kay‐Uwe Wagner, Denise M. Larson, +6

Nature Genetics

Conditional MutationTumor BiologyTumour FormationDevelopmental BiologyBlunted Ductal Morphogenesis +10

Identification of a RING protein that can interact in vivo with the BRCA1 gene product

Leeju C. Wu, Zhuo Wei Wang, Julia Tsou Tsan, +7

Nature Genetics

Natural SciencesProtein GeneticsMolecular BiologyGene CharacterizationMolecular Genetics +5

The Tumor Suppressor Gene Brca1 Is Required for Embryonic Cellular Proliferation in the Mouse

Razqallah Hakem, José Luís de la Pompa, Christian Sirard, +12

Cell

Tumor BiologyEmbryonic Cellular ProliferationDevelopmental BiologyMedicineCell Proliferation +6