Potent and specific inhibition of mammalian histone deacetylase both in vivo and in vitro by trichostatin A.

Minoru Yoshida, Masako Kijima, Motomu Akita, +1

Journal of Biological Chemistry

Histone ModificationsMolecular BiologyEpigeneticsTumor BiologyFriend Cell Differentiation +18

Structures of a histone deacetylase homologue bound to the TSA and SAHA inhibitors

Michael S. Finnin, Jill R. Donigian, Alona Cohen, +5

Nature

Histone ModificationsChromatinChromatin StructureBiochemistryChromatin Remodeling +9

Determination ofD-amino acids. II. Use of a bifunctional reagent, 1,5-difluoro-2,4-dinitrobenzene

Peter S. Marfey

Carlsberg Research Communications

Determination Ofd-amino AcidsDerivative (Chemistry)Chemical MeasurementEngineeringBiochemistry +8

A class of hybrid polar inducers of transformed cell differentiation inhibits histone deacetylases

Victoria M. Richon, Stéphane Emiliani, Eric Verdin, +4

Proceedings of the National Academy of Sciences

An Efficient Synthesis of Optically Active α-(<i>t</i>-Butoxycarbonylamino)-aldehydes from α-Amino Acids

Jean‐Alain Fehrentz, Bertrand Castro

Synthesis

EngineeringOrganic ChemistryChemistrySynthetic ChemistryEnantioselective Synthesis +2

Amide Analogues of Trichostatin A as Inhibitors of Histone Deacetylase and Inducers of Terminal Cell Differentiation

Manfred Jung, Gerald Brosch, Doris Kölle, +3

Journal of Medicinal Chemistry

Inhibitors of Human Histone Deacetylase:  Synthesis and Enzyme and Cellular Activity of Straight Chain Hydroxamates

Stacy Remiszewski, Lidia Sambucetti, Peter Atadja, +8

Journal of Medicinal Chemistry

Structural specificity for biological activity of trichostatin a, a specific inhibitor of mammalian cell cycle with potent differentiation-inducing activity in friend leukemia cells.

Minoru Yoshida, Yutaka Hoshikawa, Koshi Koseki, +2

The Journal of Antibiotics

Analogues of trichosтatin a and trapoxin B as histone deacetylase inhibitors

Manfred Jung, Katharina Hoffmann, Gerald Brosch, +1

Bioorganic & Medicinal Chemistry Letters

Medicinal ChemistryBiochemistryMedicineNatural SciencesHistone Deacetylase Inhibitors +5

Structurally Simple Trichostatin A-Like Straight Chain Hydroxamates as Potent Histone Deacetylase Inhibitors

Soon Hyung Woo, Sylvie Fréchette, Elie Abou Khalil, +11

Journal of Medicinal Chemistry

Medicinal ChemistryBiochemistryOncogenic AgentMedicineNatural Sciences +11