C10ORF10/DEPP, a transcriptional target of FOXO3, regulates ROS-sensitivity in human neuroblastoma - Concepedia

Concepedia

Publication | Open Access

C10ORF10/DEPP, a transcriptional target of FOXO3, regulates ROS-sensitivity in human neuroblastoma

DOI Full Paper Access

56

Citations

39

References

2014

Year

Stefan Salcher, Judith Hagenbuchner, Kathrin Geiger, Maximilian A. Seiter, Johannes Rainer, Reinhard Kofler, Martin Hermann, Ursula Kiechl‐Kohlendorfer, Michael J. Ausserlechner, Petra Obexer

Molecular Cancer

Abstract

The combined data indicate that in neuroblastoma DEPP localizes to peroxisomes and mitochondria and impairs cellular ROS detoxification, which sensitizes tumor cells to ROS-induced cell death.

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