p16/CDKN2 alterations and pRb expression in oesophageal squamous carcinoma. - Concepedia

Concepedia

Publication | Open Access

p16/CDKN2 alterations and pRb expression in oesophageal squamous carcinoma.

DOI Full Paper Access

24

Citations

30

References

1998

Year

Graziella Busatto, Yih‐Horng Shiao, A. Parenti, Raffaele Baffa, Alberto Ruol, Mario Plebani, Massimo Rugge

Molecular Pathology

Abstract

These results indicate that p16/CDKN2 mutations occur infrequently in oesophageal squamous carcinoma. The alteration of the Rb gene is suggested as an important step in the development of these tumours.

References

	Year	Citations
Molecular cloning: A laboratory manual Prescott L. Deininger Analytical Biochemistry Molecular BiotechnologyNatural SciencesGeneticsDna ReplicationMolecular Biology	1990	86.2K
A new regulatory motif in cell-cycle control causing specific inhibition of cyclin D/CDK4 Manuel Serrano, Gregory J. Hannon, David Beach Nature Specific InhibitionTranscriptional RegulationSignal TransductionCell RegulationCell Division	1993	3.7K
5′ CpG island methylation is associated with transcriptional silencing of the tumour suppressor p16/CDKN2/MTS1 in human cancers Adrian Merlo, James G. Herman, Li Mao, Nature Medicine Tumor BiologyTranscriptional RegulationMedicineTumour Suppressor P16/cdkn2/mts1Dna Methylation	1995	2K
Retinoblastoma-protein-dependent cell-cycle inhibition by the tumour suppressor p16 Jiří Lukáš, David Parry, Louise Aagaard, Nature Tumor BiologyCell RegulationRetinoblastoma-protein-dependent Cell-cycle InhibitionCell CycleTumor Suppressor	1995	895
Methylation of the 5' CpG island of the p16/CDKN2 tumor suppressor gene in normal and transformed human tissues correlates with gene silencing. Mirella Gonzalez‐Zulueta, Christina M. Bender, A S Yang, PubMed Epigenetic ChangeGeneticsDna MethylationEpigeneticsTumor Biology	1995	712
Mutations and altered expression of p16INK4 in human cancer. Aikou Okamoto, Douglas J. Demetrick, Elisa A. Spillare, Proceedings of the National Academy of Sciences Tumor BiologyTranscriptional RegulationAltered ExpressionCell RegulationG1 Checkpoint	1994	543
Growth suppression by p16ink4 requires functional retinoblastoma protein. René H. Medema, Rafael E. Herrera, Felix H. Lam, Proceedings of the National Academy of Sciences Signal TransductionDevelopmental BiologySignaling PathwayRetinoblastoma ProteinCell Proliferation	1995	438
Transcriptional repression of the D-type cyclin-dependent kinase inhibitor p16 by the retinoblastoma susceptibility gene product pRb. Yan Li, M.A. Nichols, J W Shay, PubMed Molecular RegulationMolecular BiologyP16 MrnaCell CycleTranscriptional Repression	1994	366
Altered expression of the cyclin D1 and retinoblastoma genes in human esophageal cancer. Wei Jiang, Y J Zhang, Scott M. Kahn, Proceedings of the National Academy of Sciences Gene AmplificationEsophageal CancerCyclin D1PathologyCancer Biology	1993	366
Lack of cyclin D-Cdk complexes in Rb-negative cells correlates with high levels of p16INK4/MTS1 tumour suppressor gene product. David Parry, Stewart Bates, David J. Mann, The EMBO Journal Tumor BiologyCell RegulationMedicineCyclin D-cdk ComplexesCancer Cell Biology	1995	355

Page 1