Concepedia

The immunosuppressant drug, thalidomide, improves hepatic alterations induced by a high-fat diet in mice

Livia de Fraia Pinto, Cecília Melleti Compri, João Victor Fornari, Waldemar Bartchewsky, Dennys E. Cintra, Miriam Trevisan, Patrícia de Oliveira Carvalho, Marcelo Lima Ribeiro, Lı́cio A. Velloso, Mário J.A. Saad,

Liver International · 2010 · 45 citations · 24 references

DOI

Abstract

We suggest that immunosuppressant drugs that target TNF-alpha and that may also contribute to reductions in the inflammatory markers that are associated with obesity could be a therapeutic option in NAFLD and type 2 diabetes.

References

24

Analysis of Relative Gene Expression Data Using Real-Time Quantitative PCR and the 2−ΔΔCT Method

Kenneth J. Livak, Thomas D. Schmittgen · Methods · 2001 · 176.9K citations

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Serum triglycerides determined colorimetrically with an enzyme that produces hydrogen peroxide.

P Fossati, L Prencipe · Clinical Chemistry · 1982 · 2.9K citations

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IRS-1-Mediated Inhibition of Insulin Receptor Tyrosine Kinase Activity in TNF-α- and Obesity-Induced Insulin Resistance

Gökhan S. Hotamışlıgil, Pascal Peraldi, Adriane I. Budavari et al. · Science · 1996 · 2.6K citations

Molecular mediators of hepatic steatosis and liver injury

Jeffrey D. Browning, Jay D. Horton · Journal of Clinical Investigation · 2004 · 1.8K citations · Full text

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Overexpression of Monocyte Chemoattractant Protein-1 in Adipose Tissues Causes Macrophage Recruitment and Insulin Resistance

Nozomu Kamei, Kazuyuki Tobe, Ryo Suzuki et al. · Journal of Biological Chemistry · 2006 · 893 citations · Full text