Reciprocal developmental pathways for the generation of pathogenic effector TH17 and regulatory T cells

Estelle Bettelli, Yijun Carrier, Wenda Gao, +5

Nature

Developmental BiologyAutoimmune DiseaseLymphocyte DevelopmentImmune Cell DevelopmentAdaptive Immune System +11

The Orphan Nuclear Receptor RORγt Directs the Differentiation Program of Proinflammatory IL-17+ T Helper Cells

Ivaylo I. Ivanov, Brent S. McKenzie, Liang Zhou, +5

Cell

InflammationCytokineLymphocyte DevelopmentImmune RegulationImmunology +7

Interleukin 17–producing CD4+ effector T cells develop via a lineage distinct from the T helper type 1 and 2 lineages

Laurie E. Harrington, Robin D. Hatton, Paul R. Mangan, +4

Nature Immunology

Lymphocyte DevelopmentImmune Cell DevelopmentAdaptive Immune SystemImmunologyT Cell Immunity +8

A distinct lineage of CD4 T cells regulates tissue inflammation by producing interleukin 17

Heon Park, Zhaoxia Li, Xuexian O. Yang, +8

Nature Immunology

InflammationAutoimmune DiseaseTissue InflammationLymphocyte DevelopmentT-regulatory Cell +9

TGFβ in the Context of an Inflammatory Cytokine Milieu Supports De Novo Differentiation of IL-17-Producing T Cells

Marc Veldhoen, Richard J. Hocking, Christopher J. Atkins, +2

Immunity

InflammationCytokineLymphocyte DevelopmentImmune Cell DevelopmentImmunology +7

Transforming growth factor-β induces development of the TH17 lineage

Paul R. Mangan, Laurie E. Harrington, Darrell B. O’Quinn, +7

Nature

Developmental BiologyTh17 LineageCell ProliferationCell GrowthGene Expression +1

T Helper 17 Lineage Differentiation Is Programmed by Orphan Nuclear Receptors RORα and RORγ

Xuexian O. Yang, Bhanu P. Pappu, Roza Nurieva, +11

Immunity

Cell LineageDevelopmental BiologyImmune Cell DevelopmentGeneticsGene Regulation +4

STAT3 Regulates Cytokine-mediated Generation of Inflammatory Helper T Cells

Xuexian O. Yang, Athanasia D. Panopoulos, Roza Nurieva, +4

Journal of Biological Chemistry

CD4+CD25+ regulatory T cells preserve graft-versus-tumor activity while inhibiting graft-versus-host disease after bone marrow transplantation

Matthias Edinger, Petra Hoffmann, Joerg Ermann, +4

Nature Medicine

Cell TherapyGraft-versus-host DiseaseTransplantationMarrow TransplantationT-regulatory Cell +11

Molecular Antagonism and Plasticity of Regulatory and Inflammatory T Cell Programs

Xuexian O. Yang, Roza Nurieva, Gustavo Martínez, +10

Immunity

InflammationAllergyAutoimmune DiseaseT-regulatory CellImmunology +10