Characterization of CD4<sup>+</sup>CD25<sup>+</sup> Regulatory T Cells in Patients Treated With High-Dose Interleukin-2 for Metastatic Melanoma or Renal Cell Carcinoma - Concepedia

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Characterization of CD4<sup>+</sup>CD25<sup>+</sup> Regulatory T Cells in Patients Treated With High-Dose Interleukin-2 for Metastatic Melanoma or Renal Cell Carcinoma

346

Citations

36

References

2006

Year

G Cesana, Gail DeRaffele, Seth A. Cohen, Dorota Moroziewicz, Josephine Mitcham, John Stoutenburg, Ken Cheung, Charles Hesdorffer, Seunghee Kim‐Schulze, Howard L. Kaufman

Journal of Clinical Oncology

Abstract

The number of Tregs, defined as CD4+CD25(hi) T cells is increased in patients with MM and RCC. High-dose IL-2 resulted in a significant decrease of Tregs in those patients achieving an objective clinical response to IL-2 therapy.

References

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