Concepedia

Characterization of CD4<sup>+</sup>CD25<sup>+</sup> Regulatory T Cells in Patients Treated With High-Dose Interleukin-2 for Metastatic Melanoma or Renal Cell Carcinoma

G Cesana, Gail DeRaffele, Seth A. Cohen, Dorota Moroziewicz, Josephine Mitcham, John Stoutenburg, Ken Cheung, Charles Hesdorffer, Seunghee Kim‐Schulze, Howard L. Kaufman

Journal of Clinical Oncology · 2006 · 346 citations · 36 references

DOI

Abstract

The number of Tregs, defined as CD4+CD25(hi) T cells is increased in patients with MM and RCC. High-dose IL-2 resulted in a significant decrease of Tregs in those patients achieving an objective clinical response to IL-2 therapy.

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