Sensitive digital quantification of DNA methylation in clinical samples

Methylation-specific PCR: a novel PCR assay for methylation status of CpG islands.

James G. Herman, Jeremy R. Graff, Sanna Myöhänen et al. · Proceedings of the National Academy of Sciences · 1996 · 5.6K citations · Full text

Epigenetic Change, Genetics, Dna Methylation +21

Circulating mutant DNA to assess tumor dynamics

Frank Diehl, Kerstin Schmidt, Michael A. Choti et al. · Nature Medicine · 2008 · 2.7K citations · Full text

Tumor Biology, Nucleic Acid Biomarkers, Tumor Heterogeneity +8

DNA fragments in the blood plasma of cancer patients: quantitations and evidence for their origin from apoptotic and necrotic cells.

Sabine Jahr, Hannes Hentze, Susanne Englisch et al. · PubMed · 2001 · 2.2K citations

Immunology, Dna Analysis, Pathology +21

Digital PCR

Bert Vogelstein, Kenneth W. Kinzler · Proceedings of the National Academy of Sciences · 1999 · 1.7K citations

Engineering, Somatic Variant, Tumor Heterogeneity +12

MethyLight: a high-throughput assay to measure DNA methylation

Cindy A. Eads · Nucleic Acids Research · 2000 · 1.4K citations

Medicine, Genetics, Dna Methylation +12