Comparative lesion sequencing provides insights into tumor evolution

Siân Jones, Wei-Dong Chen, Giovanni Parmigiani, +11

Proceedings of the National Academy of Sciences

Tumor BiologyOncologyTumor HeterogeneityMetastatic Tumor CellsMedicine +10

Detection in Fecal DNA of Colon Cancer–Specific Methylation of the Nonexpressed Vimentin Gene

Wei-Dong Chen, Zhifen Han, Joel Skoletsky, +14

JNCI Journal of the National Cancer Institute

Sensitive digital quantification of DNA methylation in clinical samples

Meng Li, Wei-Dong Chen, Nickolas Papadopoulos, +17

Nature Biotechnology

ChromatinSensitive Digital QuantificationMedicineEpigenetic ChangeDna Methylation +5

Inhibition of the prostaglandin-degrading enzyme 15-PGDH potentiates tissue regeneration

Yongyou Zhang, Amar Desai, Sung Yeun Yang, +29

Science

Regenerative MedicineGrowth HormonePge2 LevelsMedicineLipid Peroxidation +13

HLTF gene silencing in human colon cancer

Helen Moinova, Wei-Dong Chen, Lanlan Shen, +12

Proceedings of the National Academy of Sciences

Incomplete penetrance of familial retinoblastoma linked to germ-line mutations that result in partial loss of RB function

Gregory A. Otterson, Wei-Dong Chen, Amy Coxon, +2

Proceedings of the National Academy of Sciences

Apoptosis is associated with cleavage of a 5 kDa fragment from RB which mimics dephosphorylation and modulates E2F binding

Wei-Dong Chen, Gregory A. Otterson, Stan Lipkowitz, +3

Oncogene

Reductive StressSignal TransductionReceptor Tyrosine KinaseApoptosisAutophagy +9

Regulation of mammalian siderophore 2,5-DHBA in the innate immune response to infection

Zhuoming Liu, Scott M. Reba, Wei-Dong Chen, +6

The Journal of Experimental Medicine

Induction of DNMT3B by PGE2 and IL6 at Distant Metastatic Sites Promotes Epigenetic Modification and Breast Cancer Colonization

Jae Young So, Nicolas Skrypek, Howard H. Yang, +14

Cancer Research

Epigenetic ChangeCurrent Cancer TreatmentsCancer BiologyEpigeneticsTumor Biology +15

Ten-Year Outcomes: The Clinical Utility of Single Photon Emission Computed Tomography/Computed Tomography Capromab Pendetide (Prostascint) in a Cohort Diagnosed With Localized Prostate Cancer

Rodney J. Ellis, Deborah A. Kaminsky, Esther H. Zhou, +5

International Journal of Radiation Oncology*Biology*Physics

UrologyOncologic ImagingGenitourinary CancerClinical UtilityLocalized Prostate Cancer +7