Biocatalytic Access to α,α‐Dialkyl‐α‐amino Acids by a Mechanism‐Based Approach

Abstract

New donors—new products: Threonine aldolases (L-TA, D-TA) have now been found to accept donors other than glycine. In a simple asymmetric biocatalytic aldol reaction alanine, serine, and cysteine reacted with a range of simple acceptor aldehydes to yielded α-substituted serine derivatives (see scheme; PLP=pyridoxal phosphate).