Powerful Chiral Phase‐Transfer Catalysts for the Asymmetric Synthesis of α‐Alkyl‐ and α,α‐Dialkyl‐α‐amino Acids

Abstract

The catalytic performance of the chiral phase-transfer catalyst 1 (0.1–0.01 mol %) in the asymmetric alkylation of protected glycine and alanine derivatives exceeds that of existing catalysts. The reaction is used in the enantioselective synthesis of structurally diverse natural and non-natural α-alkyl and α,α-dialkyl-α-amino acids. Supporting information for this article is available on the WWW under http://www.wiley-vch.de/contents/jc_2002/2005/z462257_s.pdf or from the author. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.