Amelioration of autoimmune nephritis by imatinib in MRL/<i>lpr</i> mice

Abstract

These findings indicate that imatinib has a pleiotropic therapeutic effect, namely, the inhibition of PDGF signaling and immunosuppression, on the glomerulonephritis of MRL/lpr mice, which suggests a potential application of this drug in the treatment of human lupus nephritis.