Activating mutation in the tyrosine kinase JAK2 in polycythemia vera, essential thrombocythemia, and myeloid metaplasia with myelofibrosis

Ross L. Levine, Martha Wadleigh, Jan Cools, +26

Cancer Cell

Hematological MalignancyPolycythemia VeraEssential ThrombocythemiaReceptor Tyrosine KinaseMalignant Blood Disorder +9

A Tyrosine Kinase Created by Fusion of the <i>PDGFRA</i> and <i>FIP1L1</i> Genes as a Therapeutic Target of Imatinib in Idiopathic Hypereosinophilic Syndrome

Jan Cools, Daniel J. DeAngelo, Jason Gotlib, +23

New England Journal of Medicine

Mechanisms of resistance to imatinib mesylate in gastrointestinal stromal tumors and activity of the PKC412 inhibitor against imatinib-resistant mutants

Maria Dêbiec‐Rychter, Jan Cools, Herlinde Dumez, +10

Gastroenterology

Pkc412 InhibitorImatinib-resistant MutantsGastrointestinal OncologyMedicinePathology +7

Fusion of TEL, the ETS-Variant Gene 6 (ETV6), to the Receptor-Associated Kinase JAK2 as a Result of t(9; 12) in a Lymphoid and t(9; 15; 12) in a Myeloid Leukemia

Pieter J. Peeters, Sophie Raynaud, Jan Cools, +8

Blood

Germline loss-of-function mutations in SPRED1 cause a neurofibromatosis 1–like phenotype

Hilde Brems, Magdalena Chmara, Mourad Sahbatou, +12

Nature Genetics

Genome InstabilityDevelopmental BiologyMendelian DisorderGenetic DisorderGenetics +6

Fusion of NUP214 to ABL1 on amplified episomes in T-cell acute lymphoblastic leukemia

Carlos Graux, Jan Cools, Cindy Melotte, +20

Nature Genetics

Hematological MalignancyTumor BiologyMedicineMixed-phenotype Acute LeukemiaMolecular Biology +5

Exome sequencing identifies mutation in CNOT3 and ribosomal genes RPL5 and RPL10 in T-cell acute lymphoblastic leukemia

Kim De Keersmaecker, Zeynep Kalender Atak, Ning Li, +26

Nature Genetics

Hematological MalignancyMedicineGeneticsMolecular GeneticsIdentifies Mutation +4

CHIC2 deletion, a surrogate for FIP1L1-PDGFRA fusion, occurs in systemic mastocytosis associated with eosinophilia and predicts response to imatinib mesylate therapy

Animesh Pardanani, Rhett P. Ketterling, Stephanie R. Brockman, +10

Blood

Elevated serum tryptase levels identify a subset of patients with a myeloproliferative variant of idiopathic hypereosinophilic syndrome associated with tissue fibrosis, poor prognosis, and imatinib responsiveness

Amy D. Klion, Pierre Noël, Cem Akin, +5

Blood

Identification of novel fusion partners of ALK, the anaplastic lymphoma kinase, in anaplastic large‐cell lymphoma and inflammatory myofibroblastic tumor

Jan Cools, Iwona Włodarska, Riet Somers, +7

Genes Chromosomes and Cancer