Activating mutation in the tyrosine kinase JAK2 in polycythemia vera, essential thrombocythemia, and myeloid metaplasia with myelofibrosis

Ross L. Levine, Martha Wadleigh, Jan Cools, +26

Cancer Cell

Hematological MalignancyPolycythemia VeraEssential ThrombocythemiaReceptor Tyrosine KinaseMalignant Blood Disorder +9

MPLW515L Is a Novel Somatic Activating Mutation in Myelofibrosis with Myeloid Metaplasia

Yana Pikman, Benjamin H. Lee, Thomas Mercher, +14

PLoS Medicine

MPL515 mutations in myeloproliferative and other myeloid disorders: a study of 1182 patients

Animesh Pardanani, Ross L. Levine, Terra L. Lasho, +11

Blood

Acute myeloid leukemia ontogeny is defined by distinct somatic mutations

R. Coleman Lindsley, Brenton G. Mar, Emanuele Mazzola, +16

Blood

Genetic characterization of TET1, TET2, and TET3 alterations in myeloid malignancies

Omar Abdel‐Wahab, Ann Mullally, Cyrus V. Hedvat, +21

Blood

Increased neutrophil extracellular trap formation promotes thrombosis in myeloproliferative neoplasms

Ofir Wolach, Rob S. Sellar, Kimberly Martinod, +21

Science Translational Medicine

Integrated genomic analysis illustrates the central role of JAK-STAT pathway activation in myeloproliferative neoplasm pathogenesis

Raajit K. Rampal, Fátima Al‐Shahrour, Omar Abdel‐Wahab, +14

Blood

The burden of fatigue and quality of life in myeloproliferative disorders (MPDs)

Ruben A. Mesa, Joyce Niblack, Martha Wadleigh, +7

Cancer

A germline JAK2 SNP is associated with predisposition to the development of JAK2V617F-positive myeloproliferative neoplasms

Outi Kilpivaara, Semanti Mukherjee, Alison M. Schram, +13

Nature Genetics

Hematological MalignancyMedicineImmunologyHematologyPathology +8

Functional screening identifies CRLF2 in precursor B-cell acute lymphoblastic leukemia

Akinori Yoda, Yuka Yoda, Sabina Chiaretti, +22

Proceedings of the National Academy of Sciences

EngineeringMixed-phenotype Acute LeukemiaImmunologyMutant Jak2Immunotherapy +14