MPLW515L Is a Novel Somatic Activating Mutation in Myelofibrosis with Myeloid Metaplasia

Yana Pikman, Benjamin H. Lee, Thomas Mercher, +14

PLoS Medicine

MPL515 mutations in myeloproliferative and other myeloid disorders: a study of 1182 patients

Animesh Pardanani, Ross L. Levine, Terra L. Lasho, +11

Blood

Expression of a homodimeric type I cytokine receptor is required for JAK2V617F-mediated transformation

Xiaohui Lü, Ross L. Levine, Wei Tong, +5

Proceedings of the National Academy of Sciences

Targeting MTHFD2 in acute myeloid leukemia

Yana Pikman, Alexandre Puissant, Gabriela Alexe, +18

The Journal of Experimental Medicine

Primary Aml BlastsHematological MalignancyMedicineAcute Myeloid LeukemiaCancer Cell Biology +8

SYK Is a Critical Regulator of FLT3 in Acute Myeloid Leukemia

Alexandre Puissant, Nina Fenouille, Gabriela Alexe, +14

Cancer Cell

Hematological MalignancyCancer ResearchMixed-phenotype Acute LeukemiaAcute Myeloid LeukemiaImmunology +8

The menin-MLL1 interaction is a molecular dependency in <i>NUP98</i>-rearranged AML

Emily Heikamp, Jill A. Henrich, Florian Perner, +13

Blood

Nup98 GeneMolecular BiologyTumor BiologyMyeloid NeoplasiaHematological Malignancy +17

The creatine kinase pathway is a metabolic vulnerability in EVI1-positive acute myeloid leukemia

Nina Fenouille, Christopher F. Bassil, Issam Ben‐Sahra, +18

Nature Medicine

Hematological MalignancySignal TransductionBiochemistryMixed-phenotype Acute LeukemiaAutophagy +8

The OTT-MAL fusion oncogene activates RBPJ-mediated transcription and induces acute megakaryoblastic leukemia in a knockin mouse model

Thomas Mercher, Glen Raffel, Sandra Moore, +16

Journal of Clinical Investigation

Synergistic Drug Combinations with a CDK4/6 Inhibitor in T-cell Acute Lymphoblastic Leukemia

Yana Pikman, Gabriela Alexe, Giovanni Roti, +12

Clinical Cancer Research

Exploiting an Asp-Glu “switch” in glycogen synthase kinase 3 to design paralog-selective inhibitors for use in acute myeloid leukemia

Florence F. Wagner, Lina Benajiba, Arthur J. Campbell, +27

Science Translational Medicine