Hilde Brems

The NF1 tumor suppressor critically regulates TSC2 and mTOR

Cory M. Johannessen, Elizabeth E. Reczek, Marianne F. James et al. · Proceedings of the National Academy of Sciences · 2005 · 597 citations · Full text

Medicine, Genetics, Oncology +17

Patient-derived organoids from endometrial disease capture clinical heterogeneity and are amenable to drug screening

Matteo Boretto, Nina Maenhoudt, Xinlong Luo et al. · Nature Cell Biology · 2019 · 501 citations

Medicine, Gynecology, Pharmacology +9

Germline loss-of-function mutations in SPRED1 cause a neurofibromatosis 1–like phenotype

Hilde Brems, Magdalena Chmara, Mourad Sahbatou et al. · Nature Genetics · 2007 · 473 citations

Life Sciences, Genetics, Molecular Genetics +10

PRC2 loss amplifies Ras-driven transcription and confers sensitivity to BRD4-based therapies

Eline Beert, Éric Pasmant, Armelle Luscan et al. · Nature · 2014 · 469 citations

Medicine, Cancer Biology, Molecular Biology +14

Elevated Risk for MPNST in NF1 Microdeletion Patients

Hilde Brems, P. Wolkenstein, Dominique Vidaud et al. · The American Journal of Human Genetics · 2003 · 310 citations · Full text

Life Sciences, Genetics, Molecular Genetics +11