The NF1 tumor suppressor critically regulates TSC2 and mTOR

Cory M. Johannessen, Elizabeth E. Reczek, Marianne F. James, +3

Proceedings of the National Academy of Sciences

Germline loss-of-function mutations in SPRED1 cause a neurofibromatosis 1–like phenotype

Hilde Brems, Magdalena Chmara, Mourad Sahbatou, +12

Nature Genetics

Genome InstabilityDevelopmental BiologyMendelian DisorderGenetic DisorderGenetics +6

Patient-derived organoids from endometrial disease capture clinical heterogeneity and are amenable to drug screening

Matteo Boretto, Nina Maenhoudt, Xinlong Luo, +21

Nature Cell Biology

Uterine FibroidsMedicineUterine ReceptivityImplantation (Embryology)Gynecology +4

PRC2 loss amplifies Ras-driven transcription and confers sensitivity to BRD4-based therapies

Thomas De Raedt, Eline Beert, Éric Pasmant, +13

Nature

Transcriptional RegulationCell RegulationCell SignalingNatural SciencesConfers Sensitivity +10

Elevated Risk for MPNST in NF1 Microdeletion Patients

Thomas De Raedt, Hilde Brems, P. Wolkenstein, +7

The American Journal of Human Genetics

Genetic EpidemiologyRiskPathologyNf1 Microdeletion PatientsVariant Interpretation

Atypical neurofibromas in neurofibromatosis type 1 are premalignant tumors

Eline Beert, Hilde Brems, Bruno Daniëls, +13

Genes Chromosomes and Cancer

Mutations in LZTR1 drive human disease by dysregulating RAS ubiquitination

Mikhail Steklov, Silvia Pandolfi, Maria Francesca Baietti, +21

Science

Molecular Dissection of Isolated Disease Features in Mosaic Neurofibromatosis Type 1

Ophélia Maertens, Sofie De Schepper, Jo Vandesompele, +6

The American Journal of Human Genetics

Isolated Disease FeaturesNeuro-oncologySurgical PathologyHistopathologyMolecular Dissection +7

Glomus Tumors in Neurofibromatosis Type 1: Genetic, Functional, and Clinical Evidence of a Novel Association

Hilde Brems, Caroline Park, Ophélia Maertens, +14

Cancer Research

Neuro-oncologyCultured Nf1Tumor InnervationGliomaMalignant Disease +12

ComprehensiveNF1 screening on cultured Schwann cells from neurofibromas

Ophélia Maertens, Hilde Brems, Jo Vandesompele, +10

Human Mutation

Neuro-oncologyNeuroregenerationSomatic VariantGliomaTumor Heterogeneity +9