Hilde Brems

The NF1 tumor suppressor critically regulates TSC2 and mTOR

Cory M. Johannessen, Elizabeth E. Reczek, Marianne F. James et al. · Proceedings of the National Academy of Sciences · 2005 · 588 citations · Full text

Germline loss-of-function mutations in SPRED1 cause a neurofibromatosis 1–like phenotype

Hilde Brems, Magdalena Chmara, Mourad Sahbatou et al. · Nature Genetics · 2007 · 467 citations

Genome Instability, Developmental Biology, Mendelian Disorder +8

Patient-derived organoids from endometrial disease capture clinical heterogeneity and are amenable to drug screening

Matteo Boretto, Nina Maenhoudt, Xinlong Luo et al. · Nature Cell Biology · 2019 · 467 citations

Uterine Fibroids, Medicine, Uterine Receptivity +6

PRC2 loss amplifies Ras-driven transcription and confers sensitivity to BRD4-based therapies

Thomas De Raedt, Eline Beert, Éric Pasmant et al. · Nature · 2014 · 461 citations

Transcriptional Regulation, Cell Regulation, Cell Signaling +12

Elevated Risk for MPNST in NF1 Microdeletion Patients

Thomas De Raedt, Hilde Brems, P. Wolkenstein et al. · The American Journal of Human Genetics · 2003 · 301 citations · Full text

Genetic Epidemiology, Risk, Pathology +2