Gamma secretase–mediated Notch signaling worsens brain damage and functional outcome in ischemic stroke

Functional gamma‐secretase inhibitors reduce beta‐amyloid peptide levels in brain

Harry F. Dovey, Varghese John, J. P. Anderson et al. · Journal of Neurochemistry · 2001 · 879 citations · Full text

Life Sciences, Neurobiology, Neuroscience +17

Modulation of Notch Processing by γ-Secretase Inhibitors Causes Intestinal Goblet Cell Metaplasia and Induction of Genes Known to Specify Gut Secretory Lineage Differentiation

Joseph Milano, Jenny McKay, Claude Dagenais et al. · Toxicological Sciences · 2004 · 565 citations

Medicine, Medicinal Chemistry, Pharmacology +15

Notch promotes survival of pre–T cells at the β-selection checkpoint by regulating cellular metabolism

Maria Ciofani, Juan Carlos Zúñiga‐Pflücker · Nature Immunology · 2005 · 457 citations

Life Sciences, Cell Biology, Immunology +10

Involvement of Notch signaling in hippocampal synaptic plasticity

Yue Wang, Sic L. Chan, Lucio Miele et al. · Proceedings of the National Academy of Sciences · 2004 · 237 citations · Full text

Life Sciences, Neurobiology, Neuroscience +17

Notch1 inhibits neurite outgrowth in postmitotic primary neurons

Oksana Berezovska, Pamela J. McLean, Roger B. Knowles et al. · Neuroscience · 1999 · 218 citations

Life Sciences, Neurobiology, Neuroscience +14