IMPROVED SURVIVAL OF BIOLISTICALLY TRANSFECTED MOUSE ISLET ALLOGRAFTS EXPRESSING CTLA4-Ig OR SOLUBLE FAS LIGAND1

Abstract

Our results indicate that local production of human CTLA4-Ig or soluble human Fas ligand by biolistically transfected islets can promote allograft survival. This approach should be valuable as a potential immunoprotective therapeutic strategy in tissue transplantation.