Concepedia

Clinical significance of BRAF gene mutations in patients with non-small cell lung cancer.

Masashi Kobayashi, Makoto Sonobe, Tsuyoshi Takahashi, Akihiko Yoshizawa, Masashi Ishikawa, Ryutaro Kikuchi, Kenichi Okubo, Cheng‐long Huang, Hiroshi Date

PubMed · 2011 · 68 citations · 21 references

Abstract

PCR-SSCP analysis of BRAF exon 15 in NSCLC patients without other gene mutations may be sufficient to identify candidates for treatment.

References

21

Mutations of the BRAF gene in human cancer

Helen Davies, Graham R. Bignell, Charles Cox et al. · Nature · 2002 · 10.6K citations · Full text

Somatic Variant, Braf Gene, Genetics +5

Sorafenib in Advanced Hepatocellular Carcinoma

재연 정 · 2008 · 5.6K citations

Hepatology, Medicine, Pathology +5

Erlotinib in Previously Treated Non–Small-Cell Lung Cancer

Frances A. Shepherd, José Rodrigues Pereira, Tudor–Eliade Ciuleanu et al. · New England Journal of Medicine · 2005 · 5.4K citations · Full text

Mechanism of Activation of the RAF-ERK Signaling Pathway by Oncogenic Mutations of B-RAF

Paul Wan, Mathew J. Garnett, S. Mark Roe et al. · Cell · 2004 · 2.8K citations · Full text

Oncogenic Mutations, Signal Transduction, Signaling Pathway +9

High prevalence of BRAF mutations in thyroid cancer: genetic evidence for constitutive activation of the RET/PTC-RAS-BRAF signaling pathway in papillary thyroid carcinoma.

Edna Teruko Kimura, Marina N. Nikiforova, Zhaowen Zhu et al. · PubMed · 2003 · 1.5K citations

Tumor Biology, Somatic Mutation, Somatic Variant +15