Reduced Socs3 expression in adipose tissue protects female mice against obesity-induced insulin resistance

TLR4 links innate immunity and fatty acid–induced insulin resistance

Hang Shi, Maia V. Kokoeva, Karen Inouye et al. · Journal of Clinical Investigation · 2006 · 3.6K citations · Full text

Life Sciences, Immunology, Nutrition +17

A central role for JNK in obesity and insulin resistance

Jiro Hirosumi, Gürol Tuncman, Lufen Chang et al. · Nature · 2002 · 3.3K citations

Medicine, Biochemistry, Endocrinology +14

Adipose-selective targeting of the GLUT4 gene impairs insulin action in muscle and liver

E. Dale Abel, Odile D. Peroni, Jason K. Kim et al. · Nature · 2001 · 1.3K citations

Life Sciences, Endocrinology, Molecular Biology +14

SOCS-1 and SOCS-3 Block Insulin Signaling by Ubiquitin-mediated Degradation of IRS1 and IRS2

Liangyou Rui, Minsheng Yuan, Daniel Frantz et al. · Journal of Biological Chemistry · 2002 · 899 citations · Full text

Life Sciences, Biochemistry, Molecular Biology +17

SOCS3 negatively regulates IL-6 signaling in vivo

Ben A. Croker, Danielle L. Krebs, Jian‐Guo Zhang et al. · Nature Immunology · 2003 · 844 citations

Life Sciences, Cell Biology, Immunology +10