Concepedia

A first-in-man phase I tolerability and pharmacokinetic study of the cyclin-dependent kinase-inhibitor AZD5438 in healthy male volunteers

D. Ross Camidge, Dominic Smethurst, Jim Growcott, Nigel Barrass, John R. Foster, Salvatore Febbraro, Helen Swaisland, Andrew Hughes

Cancer Chemotherapy and Pharmacology · 2006 · 30 citations · 8 references

DOI

Concepts

References

8

Functional Inactivation of the Retinoblastoma Protein Requires Sequential Modification by at Least Two Distinct Cyclin-cdk Complexes

Ante S. Lundberg, Robert A. Weinberg · Molecular and Cellular Biology · 1998 · 1.1K citations

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Alterations of Rb Pathway Components Are Frequent Events in Patients with Oral Epithelial Dysplasia and Predict Clinical Outcome in Patients with Squamous Cell Carcinoma

Shilpi Soni, Anupam Kumar, Nitin Chakravarti et al. · Oncology · 2005 · 96 citations

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p16/p14(ARF) cell cycle regulatory pathways in primary neuroblastoma: p16 expression is associated with advanced stage disease.

Motoko Omura‐Minamisawa, Mitchell B. Diccianni, Ray Chang et al. · PubMed · 2001 · 55 citations

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Altered Expression of the Cell Cycle Regulatory Molecules pRb, p53 and MDM2 Exert a Synergetic Effect on Tumor Growth and Chromosomal Instability in Non-small Cell Lung Carcinomas (NSCLCs)

Vassilis G. Gorgoulis, P Zacharatos, Athanasios Kotsinas et al. · Molecular Medicine · 2000 · 40 citations · Full text

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Alterations of cell cycle regulators are less frequent in advanced non-small cell lung cancer than in resectable tumours

Mathias Gugger, Silvia Vonlanthen, H. J. Altermatt et al. · Lung Cancer · 2001 · 34 citations

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