Concepedia

Dose Tolerability

Dose Tolerability is a pharmacological construct that denotes the degree to which a given dose of a therapeutic agent can be administered without eliciting unacceptable adverse effects, distinguishing it from related efficacy-focused constructs by emphasizing safety and patient adherence thresholds.

497

Publications

27.7K

Citations

3.8K

Authors

1.4K

Institutions

Publications per year

2017–2026

134

Parents

Publications

497

Gefitinib in Combination With Paclitaxel and Carboplatin in Advanced Non–Small-Cell Lung Cancer: A Phase III Trial—INTACT 2

Roy S. Herbst, Giuseppe Giaccone, Joan H. Schiller et al. · Journal of Clinical Oncology · 2004 · 1.7K citations · Full text

, , +15

ZD1839, a Selective Oral Epidermal Growth Factor Receptor–Tyrosine Kinase Inhibitor, Is Well Tolerated and Active in Patients With Solid, Malignant Tumors: Results of a Phase I Trial

Malcolm Ranson, Lisa A. Hammond, D. K. Ferry et al. · Journal of Clinical Oncology · 2002 · 763 citations

, , +14

OlympiAD final overall survival and tolerability results: Olaparib versus chemotherapy treatment of physician’s choice in patients with a germline BRCA mutation and HER2-negative metastatic breast cancer

Mark E. Robson, Nadine Tung, PierFranco Conte et al. · Annals of Oncology · 2019 · 760 citations · Full text

, , +17

Selective Oral Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitor ZD1839 Is Generally Well-Tolerated and Has Activity in Non–Small-Cell Lung Cancer and Other Solid Tumors: Results of a Phase I Trial

Roy S. Herbst, Anne‐Marie Maddox, Mace L. Rothenberg et al. · Journal of Clinical Oncology · 2002 · 578 citations

, , +17

Intermittent Target Inhibition With Dasatinib 100 mg Once Daily Preserves Efficacy and Improves Tolerability in Imatinib-Resistant and -Intolerant Chronic-Phase Chronic Myeloid Leukemia

Neil P. Shah, Hagop M. Kantarjian, Dong‐Wook Kim et al. · Journal of Clinical Oncology · 2008 · 488 citations · Full text

, , +15

1–5 of 497

Authors

3.8K

  1. JC
    James Chih‐Hsin Yang

    National Taiwan University Hospital, Taiwan

    5 publications · 101 citations

    5

    h-index

  2. JD
    Jasper Dingemanse

    Actelion (Switzerland), Switzerland

    5 publications · 214 citations

    5

    h-index

  3. KJ
    Kenneth J. O’Byrne

    Queensland University of Technology, Australia

    4 publications · 82 citations

    4

    h-index

  4. MS
    Martin Schüler

    Essen University Hospital, Germany

    3 publications · 56 citations

    3

    h-index

  5. SL
    Susan L. McElroy

    University of Cincinnati Medical Center, United States

    3 publications · 277 citations

    3

    h-index

1–5 of 3.8K

Institutions

1.4K

  1. AstraZeneca (United Kingdom)

    Cambridge, United Kingdom

    13 h-index

    56 publications

    12K citations

  2. Novartis (Switzerland)

    Basel, Switzerland

    13 h-index

    38 publications

    2.5K citations

  3. Pfizer (United States)

    New York, United States

    13 h-index

    37 publications

    1.4K citations

  4. Sun Yat-sen University

    Guangzhou, China

    11 h-index

    66 publications

    1.8K citations

  5. Charité - Universitätsmedizin Berlin

    Berlin, Germany

    11 h-index

    37 publications

    2.5K citations

  6. Novartis (United States)

    New York, United States

    10 h-index

    25 publications

    1.8K citations

  7. The University of Texas MD Anderson Cancer Center

    Houston, United States

    10 h-index

    32 publications

    1.5K citations

  8. National Institutes of Health

    Bethesda, United States

    10 h-index

    32 publications

    1.7K citations

1–8 of 1.4K

Venues

  1. Journal of Clinical Oncology

    36 publications · 5.1K citations

    23

    h-index

  2. PubMed

    Repository · 31 publications · 869 citations

    16

    h-index

  3. The Journal of Clinical Pharmacology

    14 publications · 645 citations

    14

    h-index

  4. British Journal of Clinical Pharmacology

    BJCP · 12 publications · 528 citations

    11

    h-index

  5. Clinical Therapeutics

    10 publications · 249 citations

    10

    h-index

1–5