Overcoming Thermodynamic and Kinetic Limitations of Aldolase‐Catalyzed Reactions by Applying Multienzymatic Dynamic Kinetic Asymmetric Transformations

Abstract

Dynamic and successful: The asymmetric synthesis of 2-amino-1-phenylethanol was achieved by aminomethylation of benzaldehyde in the presence of the two enzymes L-threonine aldolase and L-tyrosine decarboxylase in a novel one-pot, two-enzyme process (see scheme). A modified method with three enzymes led to the enantioenriched amino alcohol in very high yield. Supporting information for this article is available on the WWW under http://www.wiley-vch.de/contents/jc_2002/2007/z604142_s.pdf or from the author. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.