Overcoming Thermodynamic and Kinetic Limitations of Aldolase‐Catalyzed Reactions by Applying Multienzymatic Dynamic Kinetic Asymmetric Transformations

Abstract

Dynamic and successful: The asymmetric synthesis of 2-amino-1-phenylethanol was achieved by aminomethylation of benzaldehyde in the presence of the two enzymes L-threonine aldolase and L-tyrosine decarboxylase in a novel one-pot, two-enzyme process (see scheme). A modified method with three enzymes led to the enantioenriched amino alcohol in very high yield.