Concepedia

Cisplatin-induced epigenetic activation of miR-34a sensitizes bladder cancer cells to chemotherapy

Heng Li, Yu Gan, Runlin Shi, Bin Lang, Xianguo Chen, Xia Ding, Haibing Xiao, Xiaolin Guo, Wei Guan, Zhangqun Ye,

Molecular Cancer · 2014 · 75 citations · 32 references

DOIFull text

Open access

Abstract

Cisplatin-based chemotherapy induced demethylation of miR-34a promoter and increased miR-34a expression, which in turn sensitized MIBC cells to cisplatin and decreased the tumorigenicity and proliferation of cancer cells that by reducing the production of CD44.

References

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Transactivation of miR-34a by p53 Broadly Influences Gene Expression and Promotes Apoptosis

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Calorie Restriction Reduces Oxidative Stress by SIRT3-Mediated SOD2 Activation

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