Characterization of Benidipine and Its Enantiomers’ Metabolism by Human Liver Cytochrome P450 Enzymes

Interindividual variations in human liver cytochrome P-450 enzymes involved in the oxidation of drugs, carcinogens and toxic chemicals: studies with liver microsomes of 30 Japanese and 30 Caucasians.

Tsutomu Shimada, Hiroshi Yamazaki, Mayumi Mimura et al. · Journal of Pharmacology and Experimental Therapeutics · 1994 · 2.8K citations

Medicine, Biochemistry, Pharmacology +15

Studies on the expression and metabolic capabilities of human liver cytochrome P450IIIA5 (HLp3).

Steven Wrighton, W. Brian, M.-A. Sari et al. · Molecular Pharmacology · 1990 · 403 citations

Medicine, Biochemistry, Pharmacology +12

Cytochrome P450 isoform inhibitors as a tool for the investigation of metabolic reactions catalyzed by human liver microsomes.

Martine Bourrié, Viviane Meunier, Yves Berger et al. · Journal of Pharmacology and Experimental Therapeutics · 1996 · 362 citations

Medicine, Biochemistry, Pharmacology +15

Oxidation of 4-aryl- and 4-alkyl-substituted 2,6-dimethyl-3,5-bis(alkoxycarbonyl)-1,4-dihydropyridines by human liver microsomes and immunochemical evidence for the involvement of a form of cytochrome P-450

Ronald Boecker, F. Peter Guengerich · Journal of Medicinal Chemistry · 1986 · 323 citations · Full text

Medicine, Biochemistry, Pharmacology +13

Oxidation of dihydropyridine calcium channel blockers and analogs by human liver cytochrome P-450 IIIA4

F. Peter Guengerich, William R. Brian, M. Iwasaki et al. · Journal of Medicinal Chemistry · 1991 · 263 citations

Medicine, Medicinal Chemistry, Pharmacology +16