Concepedia

An in-vitro tumour microenvironment model using adhesion to type I collagen reveals Akt-dependent radiation resistance in renal cancer cells

Lina Krasny, Nilly Shimony, Keren Tzukert, Raphael Gorodetsky, Shimon Lecht, Dirk M. Nettelbeck, Yosef S. Haviv

Nephrology Dialysis Transplantation · 2009 · 19 citations · 36 references

Open access

Abstract

Adherence to col(I) appears to be a relevant environmental cue enhancing RR in RCC cells, Akt dependently. Our results support inhibition of the PI3-kinase/Akt pathway as a radiosensitizing approach.

References

36

Disruption of epithelial cell-matrix interactions induces apoptosis

SM Frisch, H. Francis · The Journal of Cell Biology · 1994 · 3.2K citations · Full text

Anchorage Independence, Cell Regulation, Tumor Microenvironment +15

The selectivity of protein kinase inhibitors: a further update

Jenny Bain, Lorna Plater, Matt Elliott et al. · Biochemical Journal · 2007 · 2.5K citations · Full text

A molecular signature of metastasis in primary solid tumors

Sridhar Ramaswamy, Ken N. Ross, Eric S. Lander et al. · Nature Genetics · 2002 · 2.5K citations

Tumoral Pathology, Pathology, Molecular Signature +3

Matrix adhesion and Ras transformation both activate a phosphoinositide 3-OH kinase and protein kinase B/Akt cellular survival pathway

Asim Khwaja · The EMBO Journal · 1997 · 1K citations · Full text

Signal Transduction, Phosphoinositide 3-Oh Kinase, Signaling Pathway +15

Cell Adhesion Mediated Drug Resistance (CAM-DR): Role of Integrins and Resistance to Apoptosis in Human Myeloma Cell Lines

Jason S. Damiano, Anne E. Cress, Lori Hazlehurst et al. · Blood · 1999 · 855 citations · Full text