Genomics of Drug Sensitivity in Cancer (GDSC): a resource for therapeutic biomarker discovery in cancer cells

Wanjuan Yang, Jorge Soares, Patricia Greninger, +14

Nucleic Acids Research

Therapeutic Biomarker DiscoveryDrug TargetEngineeringPathologyTumor Biology +19

Systematic RNA interference reveals that oncogenic KRAS-driven cancers require TBK1

David A. Barbie, Pablo Tamayo, Jesse S. Boehm, +32

Nature

Systems BiologyOncogenic AgentMedicineKras-driven CancersCancer Biology +2

Twist, a Master Regulator of Morphogenesis, Plays an Essential Role in Tumor Metastasis

Jing Yang, Sendurai A. Mani, Joana Liu Donaher, +7

Cell

Developmental BiologyEssential RoleTumor HeterogeneityMedicineMorphogenesis +5

A Chromatin-Mediated Reversible Drug-Tolerant State in Cancer Cell Subpopulations

Sreenath V. Sharma, Diana Lee, Bihua Li, +13

Cell

ChromatinChromatin RemodelingMedicineCancer Cell BiologyCancer Cell Subpopulations +4

Systematic identification of genomic markers of drug sensitivity in cancer cells

Mathew J. Garnett, Elena J. Edelman, Sonja J. Heidorn, +51

Nature

Systematic IdentificationGenomic MarkersEngineeringTumor HeterogeneityMedicine +10

A molecular signature of metastasis in primary solid tumors

Sridhar Ramaswamy, Ken N. Ross, Eric S. Lander, +1

Nature Genetics

Tumoral PathologyPathologyMolecular SignatureMedicineTumor Microenvironment +1

Circulating Breast Tumor Cells Exhibit Dynamic Changes in Epithelial and Mesenchymal Composition

Min Yu, Aditya Bardia, Ben S. Wittner, +17

Science

Breast OncologyBiological MicroenvironmentsPathologyCancer BiologyTumor Biology +20

Circulating Tumor Cell Clusters Are Oligoclonal Precursors of Breast Cancer Metastasis

Nicola Aceto, Aditya Bardia, David T. Miyamoto, +17

Cell

Breast Cancer MetastasisTumor BiologyBreast OncologyOncologyTumor Heterogeneity +6

Multiclass cancer diagnosis using tumor gene expression signatures

Sridhar Ramaswamy, Pablo Tamayo, Ryan Rifkin, +12

Proceedings of the National Academy of Sciences

EngineeringDiagnosisPathologyGene Expression ProfilingTumor Biology +14

Efficient algorithms for mining outliers from large data sets

Sridhar Ramaswamy, Rajeev Rastogi, Kyuseok Shim

ACM SIGMOD Record

Distance-based OutliersAnomaly DetectionMachine LearningData ScienceData Mining +13