Concepedia

A Novel Route to Fully Substituted 1<i>H</i>-Pyrazoles

Yat Fan Suen, Håkon Hope, Michael H. Nantz, Makhluf J. Haddadin, Mark J. Kurth

The Journal of Organic Chemistry · 2005 · 45 citations · 9 references

DOI

Concepts

Abstract

A novel one-step synthesis route to fully substituted pyrazol-4-ols is reported. This simple yet nonobvious method for the construction of pyrazol-4-ols by the condensation-fragmentation-cyclization-extrusion reactions of thietanones with 1,2,4,5-tetrazines is reported. All of the elements of the thietanone except its sulfur are incorporated in these novel products.

References

9

Synthesis and Biological Evaluation of the 1,5-Diarylpyrazole Class of Cyclooxygenase-2 Inhibitors:  Identification of 4-[5-(4-Methylphenyl)-3- (trifluoromethyl)-1<i>H</i>-pyrazol-1-yl]benzenesulfonamide (SC-58635, Celecoxib)

Thomas D. Penning, John J. Talley, Stephen R. Bertenshaw et al. · Journal of Medicinal Chemistry · 1997 · 2K citations · Full text

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New hydroxy-pyrazoline intermediates, subtle regio-selectivity and relative reaction rate variations observed during acid catalyzed and neutral pyrazole cyclization

Timothy Norris, Roberto Colon-Cruz, David H. Brown Ripin · Organic & Biomolecular Chemistry · 2005 · 88 citations

, , +17

Discovery of zoniporide: A potent and selective sodium–hydrogen exchanger type 1 (NHE-1) inhibitor with high aqueous solubility

Angel Guzmán-Pérez, Ronald T. Wester, Mary C. Allen et al. · Bioorganic & Medicinal Chemistry Letters · 2001 · 78 citations · Full text

, , +12

Practical synthesis of bis-substituted tetrazines with two pendant 2-pyrrolyl or 2-thienyl groups, precursors of new conjugated polymers

Jadwiga Sołoducho, Jacek Doskocz, Joanna Cabaj et al. · Tetrahedron · 2003 · 58 citations

, , +14

A simple method for the synthesis of some 1,2-diazocines

Makhluf J. Haddadin, Bushra J. Agha, M.Samer Salka · Tetrahedron Letters · 1984 · 43 citations

, , +6