High throughput solubility determination with application to selection of compounds for fragment screening

Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings

Christopher A. Lipinski, Franco Lombardo, Beryl W. Dominy et al. · Advanced Drug Delivery Reviews · 1997 · 11K citations

Development Settings, Pharmaceutical Science, Drug Target +8

Trends in Solubility of Polymorphs

Madhu Pudipeddi, Abu T.M. Serajuddin · Journal of Pharmaceutical Sciences · 2005 · 496 citations

Materials Science, Macromolecular Chemistry, Engineering +3

A High-Throughput Screening Method for the Determination of Aqueous Drug Solubility Using Laser Nephelometry in Microtiter Plates

Christopher Bevan, Richard Lloyd · Analytical Chemistry · 2000 · 347 citations

Pharmaceutical Science, Engineering, Biomedical Engineering +22

Fragment screening: an introduction

Andrew R. Leach, Michael M. Hann, Jeremy N. Burrows et al. · Molecular BioSystems · 2006 · 161 citations

Hit Identification, Lead Identification, Chemistry +17

Comparison of chromatographic and spectroscopic methods used to rank compounds for aqueous solubility

Lin Pan, Quynh Ho, Ken Tsutsui et al. · Journal of Pharmaceutical Sciences · 2001 · 108 citations

Spectroscopic Methods, Solvent Extraction, Chemical Engineering +12