New Peptide Inhibitors of Type IB Topoisomerases: Similarities and Differences Vis-a-vis Inhibitors of Tyrosine Recombinases

Calculation of protein extinction coefficients from amino acid sequence data

Stanley C. Gill, Peter H. von Hippel · Analytical Biochemistry · 1989 · 5.3K citations

Life Sciences, Biochemistry, Molecular Biology +12

Camptothecin induces protein-linked DNA breaks via mammalian DNA topoisomerase I.

Y H Hsiang, Robert Hertzberg, Sidney M. Hecht et al. · Journal of Biological Chemistry · 1985 · 2.4K citations · Full text

Life Sciences, Cell Biology, Molecular Biology +15

The mechanism of topoisomerase I poisoning by a camptothecin analog

Bart L. Staker, Kathryn A. Hjerrild, M.D. Feese et al. · Proceedings of the National Academy of Sciences · 2002 · 802 citations · Full text

Medicine, Oncology, Pharmacology +14

DNA flexibility studied by covalent closure of short fragments into circles.

David Shore, Jörg Langowski, Robert L. Baldwin · Proceedings of the National Academy of Sciences · 1981 · 467 citations · Full text

Life Sciences, Biology, Molecular Biology +13

Conservation of Structure and Mechanism between Eukaryotic Topoisomerase I and Site-Specific Recombinases

Chonghui Cheng, Paul Kussie, Nikola P. Pavletich et al. · Cell · 1998 · 234 citations · Full text

Life Sciences, Biochemistry, Molecular Biology +10