Concepedia

Administration of Endotoxin Associated with Lipopolysaccharide Tolerance Protects Mice against Fungal Infection

Naïma Rayhane, Catherine Fitting, Olivier Lortholary, Françoise Dromer, Jean‐Marc Cavaillon

Infection and Immunity · 2000 · 63 citations · 25 references

DOIFull text

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Concepts

Abstract

Lipopolysaccharide (LPS) pretreatment of mice resulted in a significantly enhanced survival after disseminated Cryptococcus neoformans infection. The survival was associated with reduced fungal burden in tissues. LPS-pretreated mice had lower levels of cytokines in blood, spleen, and lungs and higher levels in brain. Pentoxifylline abolished the beneficial effect of LPS pretreatment.

References

25

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, , +15

Synergy between tumor necrosis factor and bacterial products causes hemorrhagic necrosis and lethal shock in normal mice.

Jay L. Rothstein, Hans Schreiber · Proceedings of the National Academy of Sciences · 1988 · 261 citations · Full text

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Afferent phase production of TNF-alpha is required for the development of protective T cell immunity to Cryptococcus neoformans

Gary B. Huffnagle, Galen B. Toews, Micki Burdick et al. · The Journal of Immunology · 1996 · 219 citations · Full text

Cytokine enhancement of complement‐dependent phagocytosis by macrophages: synergy of tumor necrosis factor‐α and granulocyte‐macrophage colony‐stimulating factor for phagocytosis of <i>Cryptococcus neoformans</i>

Helen Collins, Gregory J. Bancroft · European Journal of Immunology · 1992 · 175 citations

Interferon Appearance Stimulated by Endotoxin, Bacteria, or Viruses in Mice Pre-Treated with Escherichia coli Endotoxin or Infected with Mycobacterium tuberculosis

Julius S. Youngner, Warren R. Stinebring · Nature · 1965 · 141 citations

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