A Wireless Bio-MEMS Sensor for C-Reactive Protein Detection Based on Nanomechanics

Abstract

A quick (> 30min.), label-free detection of disease-related C-reactive proteins (CRP) is achieved using a 200μm MEMS microcantilever housed in a 7times7mm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> reaction chamber. The deflection of the cantilever due to specific CRP/anti-CRP binding is detected using a position-sensitive photodiode and the converted bio-signal is transmitted by a wireless ASK transceiver IC fabricated in a 0.18μm CMOS process. CRP concentrations from 1μg/mL to 500μg/mL can be detected. A 0.2Hz 1V ac signal is applied to the bio-MEMS sensor to unbind CRP from the cantilever for reuse