EFFECT OF P-GLYCOPROTEIN-MEDIATED EFFLUX ON CEREBROSPINAL FLUID/PLASMA CONCENTRATION RATIO

Absence of the mdr1a P-Glycoprotein in mice affects tissue distribution and pharmacokinetics of dexamethasone, digoxin, and cyclosporin A.

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Medicine, Pharmacokinetics, Pharmacology +17

The drug transporter P-glycoprotein limits oral absorption and brain entry of HIV-1 protease inhibitors.

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L-735,524: an orally bioavailable human immunodeficiency virus type 1 protease inhibitor.

Joseph P. Vacca, Bruce D. Dorsey, William A. Schleif et al. · Proceedings of the National Academy of Sciences · 1994 · 526 citations

Medicine, Pharmacokinetics, Pharmacology +17

In Vitro Substrate Identification Studies for P-glycoprotein-Mediated Transport: Species Difference and Predictability of in Vivo Results

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In vitro correlates of benzodiazepine cerebrospinal fluid uptake, pharmacodynamic action and peripheral distribution.

R Arendt, David J. Greenblatt, Rudolph H. deJong et al. · Journal of Pharmacology and Experimental Therapeutics · 1983 · 152 citations

Medicine, Pharmacokinetics, Pharmacology +13