Concepedia

Free Fraction

Free Fraction is the proportion of unbound, biologically active drug or toxin in maternal plasma that is available for passive diffusion across the placenta, distinguishing it from protein-bound or sequestered forms that do not readily transfer to the fetal compartment.

712

Publications

32K

Citations

3K

Authors

796

Institutions

Publications per year

2017–2026

60

Parents

Publications

712

Assessment of the Free Fraction of 25-Hydroxyvitamin D in Serum and Its Regulation by Albumin and the Vitamin D-Binding Protein *

Daniel D. Bikle, ELAINE GEE, Bernard P. Halloran et al. · The Journal of Clinical Endocrinology & Metabolism · 1986 · 614 citations

, , +14

In vitro synthesis and processing of a putative precursor for the small subunit of ribulose-1,5-bisphosphate carboxylase of Chlamydomonas reinhardtii.

B Dobberstein, G Blobel, N H Chua · Proceedings of the National Academy of Sciences · 1977 · 334 citations

, , +13

Mycophenolic acid binding to human serum albumin: characterization and relation to pharmacodynamics

Irena Nowak, Leslie M. Shaw · Clinical Chemistry · 1995 · 313 citations

, , +15

Central Nervous System Drug Disposition: The Relationship between in Situ Brain Permeability and Brain Free Fraction

Scott Summerfield, Kevin D. Read, David J. Begley et al. · Journal of Pharmacology and Experimental Therapeutics · 2007 · 284 citations

, , +17

Nonspecific binding to microsomes: impact on scale-up of in vitro intrinsic clearance to hepatic clearance as assessed through examination of warfarin, imipramine, and propranolol.

R S Obach · PubMed · 1997 · 281 citations

, , +17

1–5 of 712

Authors

3K

  1. DJ
    David J. Greenblatt

    Tufts University, United States

    15 publications · 699 citations

    14

    h-index

  2. GL
    Gerhard Levy

    University at Buffalo, State University of New York, United States

    11 publications · 593 citations

    11

    h-index

  3. EP
    Emilio Perucca

    University of Pavia, Italy

    9 publications · 259 citations

    9

    h-index

  4. RI
    Richard I. Shader

    Tufts University, United States

    9 publications · 525 citations

    9

    h-index

  5. HR
    Hermann R. Ochs

    Tufts Medical Center, United States

    8 publications · 353 citations

    8

    h-index

1–5 of 3K

Institutions

796

  1. Karolinska Institutet

    Stockholm, Sweden

    15 h-index

    54 publications

    2.9K citations

  2. University of Washington

    Seattle, United States

    14 h-index

    52 publications

    1.9K citations

  3. University at Buffalo, State University of New York

    Buffalo, United States

    14 h-index

    46 publications

    2.6K citations

  4. Tufts Medical Center

    Boston, United States

    13 h-index

    56 publications

    2.9K citations

  5. United States Department of Veterans Affairs

    Washington, United States

    11 h-index

    35 publications

    1.7K citations

  6. University of Bologna

    Bologna, Italy

    9 h-index

    38 publications

    1.2K citations

  7. National Institutes of Health

    Bethesda, United States

    9 h-index

    47 publications

    4.5K citations

  8. Utrecht University

    Utrecht, The Netherlands

    8 h-index

    17 publications

    641 citations

1–8 of 796

Venues

  1. Clinical Pharmacology & Therapeutics

    CPT · 51 publications · 2.6K citations

    30

    h-index

  2. PubMed

    Repository · 44 publications · 1.7K citations

    22

    h-index

  3. British Journal of Clinical Pharmacology

    BJCP · 29 publications · 1.3K citations

    22

    h-index

  4. Therapeutic Drug Monitoring

    33 publications · 865 citations

    20

    h-index

  5. The Journal of Clinical Endocrinology & Metabolism

    JCEM · 18 publications · 1.6K citations

    18

    h-index

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