Concepedia

In Vitro Substrate Identification Studies for P-glycoprotein-Mediated Transport: Species Difference and Predictability of in Vivo Results

Masayo Yamazaki, William Neway, Tomoyuki Ohe, I‐Wu Chen, Janice Rowe, Jerome Hochman, Masato Chiba, Jiunn H. Lin

Journal of Pharmacology and Experimental Therapeutics · 2001 · 237 citations · 27 references

DOI

Concepts

References

27

Disruption of the mouse mdr1a P-glycoprotein gene leads to a deficiency in the blood-brain barrier and to increased sensitivity to drugs

Alfred H. Schinkel, Jasper Smit, Olaf van Tellingen et al. · Cell · 1994 · 2.3K citations

, , +14

P-glycoprotein in the blood-brain barrier of mice influences the brain penetration and pharmacological activity of many drugs.

Alfred H. Schinkel, Els Wagenaar, Carla A.A.M. Mol et al. · Journal of Clinical Investigation · 1996 · 1.3K citations · Full text

, , +15

Absence of the mdr1a P-Glycoprotein in mice affects tissue distribution and pharmacokinetics of dexamethasone, digoxin, and cyclosporin A.

Alfred H. Schinkel, Els Wagenaar, Liesbeth van Deemter et al. · Journal of Clinical Investigation · 1995 · 1.1K citations · Full text

, , +17

The drug transporter P-glycoprotein limits oral absorption and brain entry of HIV-1 protease inhibitors.

Richard B. Kim, Martin F. Fromm, Christoph Wandel et al. · Journal of Clinical Investigation · 1998 · 1.1K citations · Full text

, , +17

P-Glycoprotein, a gatekeeper in the blood–brain barrier

Alfred H. Schinkel · Advanced Drug Delivery Reviews · 1999 · 954 citations

, , +8