I‐Wu Chen

A naphthyridine carboxamide provides evidence for discordant resistance between mechanistically identical inhibitors of HIV-1 integrase

Daria J. Hazuda, Neville J. Anthony, Robert Gomez et al. · Proceedings of the National Academy of Sciences · 2004 · 332 citations · Full text

Hiv-1 Integrase, Immunology, Cell Culture +17

In Vitro Substrate Identification Studies for P-glycoprotein-Mediated Transport: Species Difference and Predictability of in Vivo Results

Masayo Yamazaki, William Neway, Tomoyuki Ohe et al. · Journal of Pharmacology and Experimental Therapeutics · 2001 · 237 citations

Design and Synthesis of a Series of Potent and Orally Bioavailable Noncovalent Thrombin Inhibitors That Utilize Nonbasic Groups in the P1 Position

Thomas J. Tucker, Stephen F. Brady, William C. Lumma et al. · Journal of Medicinal Chemistry · 1998 · 105 citations · Full text

Pharmaceutical Science, Bioorganic Chemistry, Pharmacotherapy +18

Efficacious, Orally Bioavailable Thrombin Inhibitors Based on 3-Aminopyridinone or 3-Aminopyrazinone Acetamide Peptidomimetic Templates

Philip E.J. Sanderson, Terry A. Lyle, Kellie J. Cutrona et al. · Journal of Medicinal Chemistry · 1998 · 85 citations · Full text

Thrombosis, Medicinal Chemistry, Pharmacological Study +15

Effect of dexamethasone on the intestinal first-pass metabolism of indinavir in rats: evidence of cytochrome P-450 3A [correction of P-450 A] and p-glycoprotein induction .

Jiunn H. Lin, Masato Chiba, I‐Wu Chen et al. · PubMed · 1999 · 83 citations

Inflammation, Molecular Pharmacology, Pharmacological Study +15