European Journal of Organic Chemistry · 2007 · 53 citations · 18 references
Life SciencesBiochemistryMicrobiologyBioorganic ChemistryMycologyOrganic ChemistryFungal BiochemistryFungal MetabolismFungal Natural Product BiosynthesisFungal Secondary MetabolitesPolyketide BiosynthesisSecondary Metabolite BiosynthesisFungal Biochemical PathwaysFungal Metabolite BiosynthesisFungal Polyketide BiosynthesisMarine Fungal Secondary MetabolitesMicrobial Production Of PolyketidesPolyketide Precursor BiosynthesisStructure Elucidation Of Fungal Metabolites
Abstract Three new fungal polyketide metabolites, chaetocyclinone A to C, were produced by cultures of Chaetomium sp. (strain Gö 100/2), which was isolated from marine algae. The structures of the novel compounds were established by detailed spectroscopic analysis. Additionally, an X‐ray analysis of chaetocyclinone C ( 5 ) was performed. Chaetocyclinone A ( 1 ) exhibits inhibitory activity against selected phytopathogenic fungi. The biosynthesis of 1 and 5 was studied by feeding 13 C‐labelled acetate. The results suggest the polyketide pathway for the isolated metabolites. In the case of chaetocyclinone C ( 5 ), we assume an unusual condensation of two highly reactive heptaketide intermediates. (© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2007)
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